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存在镜面反射时的双目立体匹配

卢思军,唐振民,郭龙源,卢阿丽

《中国工程科学》 2010年 第12卷 第1期   页码 56-60

摘要：

传统的立体匹配方法建立在Lambertian的漫反射模型之上，漫反射模型的立体匹配在一个图像的大多部分是有效的，但是在处理图像中包含镜面反射的部分时结果会产生严重的匹配错误。笔者利用漫反射和镜面反射在灰度和最大色度上的不同，分离出镜面反射的像素，然后采用一种针对镜面反射的匹配测度，在图像中漫反射部分和镜面反射部分都能匹配得到正确的视差。结果证明了方法的有效性。

关键词： 立体匹配     漫反射     镜面反射     色度    

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Photocatalytic activity of ZnO films with micro-grid structure

Chunzhi LI , Wenwen WANG , Junying ZHANG , Hailing ZHU , Weiwei ZHANG , Tianmin WANG ,

《环境科学与工程前沿（英文）》 2009年 第3卷 第3期   页码 289-293 doi: 10.1007/s11783-009-0034-3

摘要： A layer of zinc oxide (ZnO) micro-grid was deposited on the surface of ZnO film using the DC reactive magnetron sputtering method and the micro-sphere lithography technique on glass substrates. Samples of this layer were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), atomic force microscopy (AFM), and ultraviolet-visible light spectroscopy. X-ray diffraction showed the high crystallinity of ZnO film and the regular arrangement of the micro-grid. The micro-grid ZnO has a lower specular reflection and a higher diffuse reflection, allowing incident light to reflect two or three times to enhance the usage of light. Photocatalytic degradation experiments on methylene blue using both ZnO micro-grid and ordinary film showed that the ZnO micro-grid has better photocatalytic properties than ordinary film. The ZnO micro-grid enhanced the photocatalytic efficiency of ZnO film by 28% with a degradation time of 300min.

关键词： Photocatalysis     ZnO micro-grid     polystyrene latex spheres template     diffuse reflection    

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Fully integrated approach: an alternative solution of coupling a GIS and diffuse pollution models

S. LIU,R.E. BRAZIER,A. L. HEATHWAITE,W. LIU

《环境科学与工程前沿（英文）》 2014年 第8卷 第4期   页码 616-623 doi: 10.1007/s11783-013-0589-x

摘要： As a tool for management, query, visualization and analysis of spatially referred information, GIS has been recognized as a method to aid the modeling of diffuse pollution and visualize the results in a spatial context. A common question in integrating diffuse pollution models and GIS is to choose a suitable coupling approach, in which the feature of diffuse pollution models should be taken into account. In this paper, we report on our experience in coupling a distributed diffuse pollution model with a GIS. A prototype of fully integrated system is developed in this paper. This system has high flexibility, extendibility and great data management efficiency. Differences in applicability of loose coupling, tight coupling and fully integrated approaches are addressed. It is concluded that the fully integrated approach can avoid tanglesome data exchange and routine execution and more robust than loose and tight coupling approaches and is suitable for distributed diffuse pollution modes.

关键词： diffuse pollution     GIS     modeling     nutrients     phosphorus    

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Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

《医学前沿（英文）》 2023年 第17卷 第2期   页码 240-262 doi: 10.1007/s11684-022-0936-z

摘要： Detailed characterizations of genomic alterations have not identified subtype-specific vulnerabilities in adult gliomas. Mapping gliomas into developmental programs may uncover new vulnerabilities that are not strictly related to genomic alterations. After identifying conserved gene modules co-expressed with EGFR or PDGFRA (EM or PM), we recently proposed an EM/PM classification scheme for adult gliomas in a histological subtype- and grade-independent manner. By using cohorts of bulk samples, paired primary and recurrent samples, multi-region samples from the same glioma, single-cell RNA-seq samples, and clinical samples, we here demonstrate the temporal and spatial stability of the EM and PM subtypes. The EM and PM subtypes, which progress in a subtype-specific mode, are robustly maintained in paired longitudinal samples. Elevated activities of cell proliferation, genomic instability and microenvironment, rather than subtype switching, mark recurrent gliomas. Within individual gliomas, the EM/PM subtype was preserved across regions and single cells. Malignant cells in the EM and PM gliomas were correlated to neural stem cell and oligodendrocyte progenitor cell compartment, respectively. Thus, while genetic makeup may change during progression and/or within different tumor areas, adult gliomas evolve within a neurodevelopmental framework of the EM and PM molecular subtypes. The dysregulated developmental pathways embedded in these molecular subtypes may contain subtype-specific vulnerabilities.

关键词： glioma progression     molecular classification     EM/PM subtyping     intratumor heterogeneity    

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Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

《医学前沿（英文）》 2023年 第17卷 第4期   页码 699-713 doi: 10.1007/s11684-022-0972-8

摘要： Anti-CD19 chimeric antigen receptor (CAR)-T cell therapy has achieved 40%–50% long-term complete response in relapsed or refractory diffuse large B-cell lymphoma (DLBCL) patients. However, the underlying mechanism of alterations in the tumor microenvironments resulting in CAR-T cell therapy failure needs further investigation. A multi-center phase I/II trial of anti-CD19 CD28z CAR-T (FKC876, ChiCTR1800019661) was conducted. Among 22 evaluable DLBCL patients, seven achieved complete remission, 10 experienced partial remissions, while four had stable disease by day 29. Single-cell RNA sequencing results were obtained from core needle biopsy tumor samples collected from long-term complete remission and early-progressed patients, and compared at different stages of treatment. M2-subtype macrophages were significantly involved in both in vivo and in vitro anti-tumor functions of CAR-T cells, leading to CAR-T cell therapy failure and disease progression in DLBCL. Immunosuppressive tumor microenvironments persisted before CAR-T cell therapy, during both cell expansion and disease progression, which could not be altered by infiltrating CAR-T cells. Aberrant metabolism profile of M2-subtype macrophages and those of dysfunctional T cells also contributed to the immunosuppressive tumor microenvironments. Thus, our findings provided a clinical rationale for targeting tumor microenvironments and reprogramming immune cell metabolism as effective therapeutic strategies to prevent lymphoma relapse in future designs of CAR-T cell therapy.

关键词： anti-CD19 chimeric antigen receptor T     immunotherapy     diffuse large B cell lymphoma     tumor microenvironment     tumor-associated macrophage     metabolism    

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Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German

Muhammad WASEEM, Frauke KACHHOLZ, Jens TRÄNCKNER

《农业科学与工程前沿（英文）》 2018年 第5卷 第4期   页码 420-431 doi: 10.15302/J-FASE-2018243

摘要：

Various process-based models are extensively being used to analyze and forecast catchment hydrology and water quality. However, it is always important to select the appropriate hydrological and water quality modeling tools to predict and analyze the watershed and also consider their strengths and weaknesses. Different factors such as data availability, hydrological, hydraulic, and water quality processes and their desired level of complexity are crucial for selecting a plausible modeling tool. This review is focused on suitable model selection with a focus on desired hydrological, hydraulic and water quality processes (nitrogen fate and transport in surface, subsurface and groundwater bodies) by keeping in view the typical lowland catchments with intensive agricultural land use, higher groundwater tables, and decreased retention times due to the provision of artificial drainage. In this study, four different physically based, partially and fully distributed integrated water modeling tools, SWAT (soil and water assessment tool), SWIM (soil and water integrated model), HSPF (hydrological simulation program– FORTRAN) and a combination of tools from DHI (MIKE SHE coupled with MIKE 11 and ECO Lab), have been reviewed particularly for the Tollense River catchment located in North-eastern Germany. DHI combined tools and SWAT were more suitable for simulating the desired hydrological processes, but in the case of river hydraulics and water quality, the DHI family of tools has an edge due to their integrated coupling between MIKE SHE, MIKE 11 and ECO Lab. In case of SWAT, it needs to be coupled with another tool to model the hydraulics in the Tollense River as SWAT does not include backwater effects and provision of control structures. However, both SWAT and DHI tools are more data demanding in comparison to SWIM and HSPF. For studying nitrogen fate and transport in unsaturated, saturated, and river zone, HSPF was a better model to simulate the desired nitrogen transformation and transport processes. However, for nitrogen dynamics and transformations in shallow streams, ECO Lab had an edge due its flexibility for inclusion of user-desired water quality parameters and processes. In the case of SWIM, most of the input data and governing equations are similar to SWAT but it does not include water bodies (ponds and lakes), wetlands and drainage systems. In this review, only the processes that were needed to simulate the Tollense River catchment were considered, however the resulted model selection criteria can be generalized to other lowland catchments in Australia, North-western Europe and North America with similar complexity.

关键词： diffuse pollution     ECO Lab     HSPF     lowland catchment     MIKE 11     MIKE SHE     modeling tools     SWAT     SWIM     Tollense River     water quality    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

《医学前沿（英文）》 2022年 第16卷 第2期   页码 285-294 doi: 10.1007/s11684-021-0843-8

摘要： Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has shown impressive efficacy in treating B-cell malignancies. A single-center phase I dose-escalation study was conducted to evaluate the safety and efficacy of T cells transduced with CBM.CD19 CAR, a second-generation anti-CD19 CAR bearing 4-1BB costimulatory molecule, for the treatment of patients with refractory diffuse large B-cell lymphoma (DLBCL). Ten heavily treated patients with refractory DLBCL were given CBM.CD19 CAR-T cell (C-CAR011) treatment. The overall response rate was 20% and 50% at 4 and 12 weeks after the infusion of C-CAR011, respectively, and the disease control rate was 60% at 12 weeks after infusion. Treatment-emergent adverse events occurred in all patients. The incidence of cytokine release syndrome in all grades and grade≥3 was 90% and 0, respectively, which is consistent with the safety profile of axicabtagene ciloleucel and tisagenlecleucel. Neurotoxicity or other dose-limiting toxicities was not observed in any dose cohort of C-CAR011 therapy. Antitumor efficacy was apparent across dose cohorts. Therefore, C-CAR011 is a safe and effective therapeutic option for Chinese patients with refractory DLBCL, and further large-scale clinical trials are warranted.

关键词： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting toxicity    

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土石坝SH 波地震反射成像 Article

Edward W. Woolery

《工程（英文）》 2018年 第4卷 第5期   页码 694-701 doi: 10.1016/j.eng.2018.08.009

摘要：

评价地下物性和地质特征成像（如断层、空洞、低速层等）是近地表地球物理学中的经典问题，这些问题通常会危害岩土工程，尤其对大型土石防洪坝这类高危结构物危害更大。在美国，由于大部分重要的基础设施在20 世纪初至20 世纪中叶设计建成，目前这些堤坝已处于设计寿命的末期，之前被人忽略的或者在设计建造过程中被认为无关紧要的细微缺陷将会对堤坝安全造成严重威胁。这些构造在高水动力条件下会加速薄弱区域的恶化，并破坏其长期完整性。仅用传统钻探技术解决大坝的相关问题通常存在不足（缺乏横向分辨率），过高的成本同样限制了钻探技术的发展。然而，有选择的岩土钻探技术与近地表地球物理相结合，尤其是对堤坝内部细小结构和地质基础条件成像方面的剪切波（shear-wave，SH 波）地震反射技术，可以有效地降低堤坝修复工程所需的成本。为支持上述观点，本文以美国中部两个防洪坝为例，对其原位组分和工程建设组分进行SH 波地震反射成像。

关键词： 地球物理     地震反射     剪切波     近地表     坝体安全    

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Treatment of severe diffuse cavernous hemangioma of the lower limb by combination of superficial femoral

Yin XIA, Dan SHANG, Qin LI, Xiaoqin RUN, Chenxi OUYANG, Yiqing LI, Bi JIN

《医学前沿（英文）》 2009年 第3卷 第2期   页码 240-244 doi: 10.1007/s11684-009-0031-8

摘要： Severe diffuse cavernous hemangioma of the lower limb is rarely seen among young people and sometimes can be a fatal challenge for operation. We reported a case of diffuse cavernous hemangioma involving both skin and muscles of the left lower limb and perineal region in an adolescent patient. The patient who had previously undergone a local hemangioma resection of the foot ultimately ended in superficial femoral artery ligation and supergenual thigh amputation of the left upper leg because of uncontrollable massive bleeding of anastomotic stoma.

关键词： cavernous hemangioma     femoral artery     ligation     amputation    

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Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

《医学前沿（英文）》 2019年 第13卷 第1期   页码 94-103 doi: 10.1007/s11684-019-0680-1

摘要：

Autoimmune diseases (ADs) increase the risk of non-Hodgkin’s lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed the data on 502 patients with DLBCL treated in our institution from January 2013 to March 2018. Survival functions were estimated using Kaplan–Meier method and Cox regression model. The 3-year progression free survival (PFS) and overall survival (OS) rates were 70.2% and 80.9%, respectively, and the complete remission (CR) rate was 78.1%. Among the patients, those with multiple (≥3) abnormal immunologic markers had significantly shorter 3-year PFS (52.7% vs. 77.3%, P<0.001) and OS (68.5% vs. 85.8%, P=0.001) than those without multiple abnormal immunologic markers. Multivariate analysis revealed that the presence of multiple abnormal immunologic markers and the elevated serum levels of lactate dehydrogenase were the independent adverse prognostic factors for PFS (P=0.008, P<0.001) and OS (P=0.003, P<0.001). Meanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P=0.001) and age>60 years for OS (P=0.014). In conclusion, the immunologic status was closely related to lymphoma progression, and this study provides new insights into the risk stratification of patients with DLBCL.

关键词： immunologic marker     diffuse large B-cell lymphoma     prognosis    

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Reflection on Development Strategy of Engineering Management Discipline in China

Ying-luo Wang

《工程管理前沿（英文）》 2014年 第1卷 第2期   页码 218-224 doi: 10.15302/J-FEM-2014029

摘要： A large number of engineering management professionals are required to promote engineering management efficiency, but the existing engineering management training system has some gaps with economical and social development in China. Development of engineering management discipline has very important strategic significance in China. This paper explores the disciplinary characteristics of engineering management, and analyzes the developmental issues about education of engineering management discipline. Meanwhile, the paper also proposes that the construction for development strategy of China’s engineering management discipline should be accelerated in the following aspects: Theoretical system of engineering management must be built and methodology of engineering management needs to be explored and perfected; advantages of various universities should be fully expressed, to show their own characteristics with accurate and reasonable positioning; knowledge system of engineering management discipline must be organized and integrated; practical ability of engineering management professionals needs to be promoted; education level of engineering management discipline should be perfected and training objectives at various levels must be clarified; teaching methods and means have to be reformed.

关键词： engineering management     disciplinary characteristics     development strategy    

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A new slicing method of reverse engineering based on the principle of refraction and reflection

LIU Ya-xiong, ZONG Xue-wen, TANG Yi-ping, LU Bing-heng

《机械工程前沿（英文）》 2006年 第1卷 第3期   页码 323-328 doi: 10.1007/s11465-006-0041-z

摘要： The traditional slicing method of reverse engineering has been used in product measure from time immemorial. This method however has the disadvantage of low contrast of the cross-sectional pictures of an object. In order to overcome the said shortcoming, a new slicing method of reverse engineering, based on the principle of refraction and reflection of a prism, has been propounded. According to the reflectivity of the object, one of the illuminating methods straight illuminating or inclined illuminating is adopted. These methods can enable one to obtain the image of the cross-section of a bright object with a dark background or the opposite. Experiments have proved to show the advantages of this new slicing method for high contrast of the cross-sectional pictures. To eliminate geometrical distortions caused by the refraction and reflection of the prism, a mathematical transformation model can be set up to correct the image by using relevant software. Eventually, a RP model of a temporomandibular joint fabricated according to its slicing pictures is illustrated.

关键词： immemorial     RP     reflection     mathematical transformation     temporomandibular    

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Diffuse cystic lung diseases

null

《医学前沿（英文）》 2013年 第7卷 第3期   页码 316-327 doi: 10.1007/s11684-013-0269-z

摘要：

Diffuse cystic lung diseases are uncommon but can present a diagnostic challenge because increasing number of diseases have been associated with this presentation. Cyst in the lung is defined as a round parenchymal lucency with a well-defined thin wall (<2 mm thickness). Focal or multifocal cystic lesions include blebs, bullae, pneumatoceles, congenital cystic lesions, traumatic lesions, and several infectious processes such as coccidioidomycosis, Pneumocystis jiroveci pneumonia, and hydatid disease. “Diffuse” distribution in the lung implies involvement of all lobes. Diffuse lung involvement with cystic lesions can be seen in pulmonary lymphangioleiomyomatosis, pulmonary Langerhans’ cell histiocytosis, lymphoid interstitial pneumonia, Birt-Hogg-Dubé syndrome, amyloidosis, light chain deposition disease, honeycomb lung associated with advanced fibrosis, and several other rare causes including metastatic disease. High-resolution computed tomography of the chest helps define morphologic features of the lung lesions as well as their distribution and associated features such as intrathoracic lymphadenopathy. Correlating the tempo of the disease process and clinical context with chest imaging findings serve as important clues to defining the underlying nature of the cystic lung disease and guide diagnostic evaluation as well as management.

关键词： cyst     lung disease     interstitial lung disease     lymphangioleiomyomatosis     Langerhans’ cell histiocytosis     Birt-Hogg-Dubé syndrome    

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Distribution and temporal variability of the solar resource at a site in south-east Norway

Muyiwa S. ADARAMOLA

《能源前沿（英文）》 2016年 第10卷 第4期   页码 375-381 doi: 10.1007/s11708-016-0426-6

摘要： Globally, solar energy is expected to play a significant role in the changing face of energy economies in the near future. However, the variability of this resource has been the main barrier for solar energy development in most locations around the world. This paper investigated the distribution and variability of solar radiation using the a 10-year (2006 to 2015) data collected at Sørås meteorological station located at latitude 59° 39′ N and longitude 10° 47′E, about 93.3 m above sea level (about 30 km from Oslo), in south-eastern part of Norway. It is found that on annual basis, the total number of days with a global solar radiation of less than 1 kWh/(m ·d) is 120 days while the total number of days with an expected global solar radiation greater than 3 kWh/(m ·d) is 156 days (42.74%) per year. The potential energy output from a horizontally placed solar collector in these 156 days is approximately 75% of the estimated annual energy output. In addition, it is found that the inter-annual coefficient of variation of the global solar radiation is 4.28%, while that of diffuse radiation is 4.96%.

关键词： coefficient of variation     global solar radiation     diffuse ratio     albedo     PV energy systems    

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Grafting of PEG400 onto the surface of LLDPE/SMA film

CHEN Gufeng, ZHANG Yi, XU Jiarui, ZHU Yafei

《化学科学与工程前沿（英文）》 2007年 第1卷 第2期   页码 128-131 doi: 10.1007/s11705-007-0024-6

摘要： Linear low-density polyethylene (LLDPE) was melt and blended with styrene-maleic anhydride copolymer (SMA). The blending films were then immersed in poly(ethylene glycol)400 (PEG400) at room temperature. The surface composition of the blend films was determined by Fourier transform infra-red spectroscopy coupled with a variable incidence angle attenuated total reflection accessory (ATR-FTIR). Results show that PEG400 can be grafted onto the surface of the films via esterification with SMA. The immersion of PEG promotes the enrichment of SMA onto the surface of the films. The water contact angle data show that grafting of PEG400 onto PE can greatly improve the hydrophilicity of the PE surface. These experiments show that surface functionalization of polyethylene films by blending SMA and then surface grafting of PEG is feasible, which suggest an effective and simple route for PE surface modification via blending and grafting.

关键词： hydrophilicity     temperature     effective     immersion     reflection accessory    

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标题 作者 时间 类型 操作

存在镜面反射时的双目立体匹配

卢思军,唐振民,郭龙源,卢阿丽

期刊论文

Photocatalytic activity of ZnO films with micro-grid structure

Chunzhi LI , Wenwen WANG , Junying ZHANG , Hailing ZHU , Weiwei ZHANG , Tianmin WANG ,

期刊论文

Fully integrated approach: an alternative solution of coupling a GIS and diffuse pollution models

S. LIU,R.E. BRAZIER,A. L. HEATHWAITE,W. LIU

期刊论文

Temporal and spatial stability of the EM/PM molecular subtypes in adult diffuse glioma

期刊论文

Immunosuppressive tumor microenvironment contributes to tumor progression in diffuse large B-cell lymphoma

期刊论文

Suitability of common models to estimate hydrology and diffuse water pollution in North-eastern German

Muhammad WASEEM, Frauke KACHHOLZ, Jens TRÄNCKNER

期刊论文

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

期刊论文

土石坝SH 波地震反射成像

Edward W. Woolery

期刊论文

Treatment of severe diffuse cavernous hemangioma of the lower limb by combination of superficial femoral

Yin XIA, Dan SHANG, Qin LI, Xiaoqin RUN, Chenxi OUYANG, Yiqing LI, Bi JIN

期刊论文

Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large

Yiwen Cao, Zhenhua Liu, Wen Wu, Ying Qian, Qin Shi, Rong Shen, Binshen Ouyang, Pengpeng Xu, Shu Cheng, Jin Ye, Yiming Lu, Chaofu Wang, Chengde Yang, Li Wang, Weili Zhao

期刊论文

Reflection on Development Strategy of Engineering Management Discipline in China

Ying-luo Wang

期刊论文

A new slicing method of reverse engineering based on the principle of refraction and reflection

LIU Ya-xiong, ZONG Xue-wen, TANG Yi-ping, LU Bing-heng

期刊论文

Diffuse cystic lung diseases

null

期刊论文

Distribution and temporal variability of the solar resource at a site in south-east Norway

Muyiwa S. ADARAMOLA

期刊论文

Grafting of PEG400 onto the surface of LLDPE/SMA film

CHEN Gufeng, ZHANG Yi, XU Jiarui, ZHU Yafei

期刊论文